Opportunities and challenges for a new approach to genomic prediction
Dorian Garrick Henderson originally described breeding values (EPDs) as sums of gene effects. Meuwissen, Hayes, Goddard re-expressed this as sums of effects estimated for genotyped DNA variants. In current selection we have two models for genetic prediction, one for genotyped animals and a separate model for animals not genotyped. You can combine a pedigree based relationship matrix with a genomic based relationship, we call this single-step BLUP or HBLUP ( Aguilar et al., 2010 ). There is a second approach which Garrick refers to as a hybrid approach. Now breeding values for nongenotyped animals are expressed as the part explained by genotyped relatives and the part not explained by genotyped relatives. This is similar to the animal model where we have the breeding value explained by relatives and the breeding value due to the random shuffle of genes across generations. This model is in press and should be out later this summer (Fernando, Dekkers and Garrick 2014 GSE). If ev