A Steak in Genomics™

My group has posted a new preprint on bioRxiv .  You can check it out here:  https://doi.org/10.1101/2020.03.11.988121 Warning, it is written for a technical audience, not in cowboy terms. So- what are the take-home messages for farmers and ranchers? We can identify the DNA variants responding to your selection decisions. You tend to select cattle that have better immune systems. Hormone production in the ovaries is under selection in Red Angus. Makes sense based on the breed's focus on fertility. Muscle development is under selection in Gelbvieh.  We can identify the DNA variants that lead to cattle adapted to their environment Blood vessel tightening or loosening is under environmental selection. The brain and neuron signaling is an important part of environmental adaptation. We are losing local adaptation in beef cattle. Check out this Twitter thread to see figures from the paper. https://twitter.com/pop_gen_JED/status/1258786262149808131 Regarding the last point, we c...

Bob Hough recently posted the following comment on Facebook (posted with his permission): Early in my career at a breed association, the much beloved American Angus breed executive told me that the secret to success running a breed association was to have a top junior program, keep the books straight, and make sure the numbers (EPDs) don't change. This philosophy meant Angus valued stability in their genetic predictions over keeping them up-to-date with the latest science. The Angus Association also marketed extremely effectively the infallibility of their EPDs because of the size of their database. I will start with the later. Yes, a database needs certain critical mass to make sure the animals are tied, but that can be achieved in a modest size database. After that, data quality far and away outweighs data quantity in assuring the most precise and reliable EPDs possible. On the former point, Angus breeders are simply not use to change. This is not the case in most breed associ...