A Steak in Genomics™

Jeremy Taylor University of Missouri Taylor is going to cover several things: GGP-F250 Imputation Haplotype diversity Embryonic Lethals The GGP-F250 is a very unique assay compared to other SNP panels. All of the other available assays (SNP panels) use common variants. The GGP-F250 has many rare variants, most of which are located in genes or other functional elements. Why is rare variation important? Most of the variation in mammalian genomes, including the genomes of cattle, contain rare variation. Most of the DNA differences between different individuals are rare variants. We can't tag this rare variation with the common variants included in most SNP panels. To accurately measure genetic differences (and predict EPDs), we have to account for rare variation. Imputation is the process of: 1. Sorting DNA variants onto each chromosome (phasing) 2. Filling in missing genotypes We can impute from 50,000 SNPs to 700,000 SNPs to 15 million variants. But, we can'...