Featured Post

Hereford and Red Angus Heifers Recruited for Genomics Research

The University of Missouri is recruiting 2,500 Hereford heifers and 2,500 Red Angus heifers to participate in a heifer puberty and fertility genomic research project. Heifers should be registered Hereford, registered Red Angus, or commercial Hereford or Red Angus. Hereford x Red Angus crossbred heifers targeted for the Premium Red Baldy Program would also be a good fit for the research project. Producers must be willing to work with a trained veterinarian to collect the following data: ReproductiveTract Scores collected at a pre-breeding exam 30 to 45 days prior to the start of the breeding season. PelvicMeasurements (height and width) collected at the same pre-breeding exam 30 to 45 days prior to the start of the breeding season. Pregnancy Determination Using Ultrasound reporting fetal age in days. Ultrasound will need to occur no later than 90 days after the start of the breeding season. In addition, heifers must have known birth dates and have weights recorded eithe

Scientific Hype Cycle

File:Gartner Hype Cycle.svg
Gartner Research's Hype Cycle diagram, by Jeremy Kemp.
27 December 2007. Used under a CC-BY-SA license.
 

I was recently told that I was being over exuberant in my promotion of genomic technologies. If I have slipped into hyperbole, it has been for two reasons:
a) An unintentional mistake.
b) Push back against the disillusionment of a valid technology.

In previous decades new DNA technologies, such as microsatellites, AFLP markers, etc, lead to a lot of hype about how the beef industry was going to be radically changed by these DNA technologies. These were the "Technology Trigger" and "Peak of Inflated Expectations" in the diagram above. I've previously described that these single gene DNA tests completely under-performed compared to expectations. Consequentially, the "Peak of Inflated Expectations" was followed by the "Trough of Disillusionment". In this period of disillusionment, two important things happened. First, Meuwissen, Hayes, and Goddard proposed a new way to use DNA markers to predict genetic merit. Rather than looking at individual genes, they suggested we use markers throughout the genome to account for 100% of the animal's DNA in these genomic predictions. Unfortunately, in 2001 the technology and capability to simultaneously test enough markers was not available. But, in 2007 a group of universities and the USDA developed a DNA panel that was release by Illumina in 2008 as the BovineSNP50 BeadChip. With this technology we could now simultaneously test over 50,000 markers evenly spaced throughout the genome. Genomic selection was implemented within the dairy industry in 2009, and later several beef breed associations followed suit.

Genomic prediction works, as the dairy industry has shown.
From Brian Van Doormaal, 2012. Increased Rates of Genetic Gain with Genomics. Canadian Dairy Network.
The rate of genetic change visually increased with the start of genomic selection in 2009. I would guess that the dairy industry is somewhere between the "Slope of Enlightenment" and the "Plateau of Productivity". Hopefully, the beef industry will leave the "Trough of Disillusionment" and start the trek up the "Slope of Enlightenment". To do this, we need to have genomic tests at price points that allow broad application within the industry, genomic tests which explain a large portion of the genetic variance, and explanations to help producers understand when and how to use these technologies.

Bottom line. Genomic selection works. And that is no hyperbole.




p.s. For those of you needing some entertainment and encouragement. Enjoy.



Comments

Anonymous said…
The beef industry is much more genetically diverse than the dairy industry, and that is a good thing(ask dairymen). It will take much more testing to establish the markers that represent the traits in the many different genetic lines of the beef industry. Don't use a race toward some established genomic standard to destroy the beef industries diversity.

Popular posts from this blog

New Show-Me-Select Sire EPD Requirements Announced

Show-Me-Select Board Approves Genomic Testing Requirement for Natural Service Sires

Bob Hough Comments on Changes at Breed Associations